| Product Name | Anti-CD17 / Lactosylceramide Monoclonal Antibody |
|---|---|
| Description | CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells. |
| Clone | MEM-68 |
| Immunogen | Pre-B cell line NALM-6 |
| Isotype | IgM |
| Specificity |
The mouse monoclonal antibody MEM-68 recognizes CD17, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets. |
| Reactivity | Human |
| Applications | FC |
| Form | Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0 |
| Storage | Store at 2-8°C. Do not freeze. |
| Background | CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells. |
| Supplier | Exbio |
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