| Product Name | Anti-CD23 Antibody [FCER2/6889] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [FCER2/6889] antibody to CD23. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | FCER2/6889 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 48-321) of human FCER2/CD23 protein. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 37 kDa (soluble form) / 45 kDa (membrane-bound form) |
| Target | CD23 |
| Specificity | CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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