Anti-CD238/Blood Group Kpbc Antigen Monoclonal Antibody, Biotin
| Product Name | Anti-CD238/Blood Group Kpbc Antigen Monoclonal Antibody, Biotin |
|---|---|
| Description | Mouse monoclonal antibody to human Blood Group Kpbc/CD238 Biotin conjugate. The Kpa, Kpb, and Kpc antigens are part of the Kell (CD 238) blood group system. The antigens of the Kell system are carried on an erythrocyte membrane glycoprotein of 93 kDa, which is firmly bound to the cytoskeleton. The antigen is found on human erythrocytes, liver sinusoidal cells4 and testis with weaker expression in a large number of other tissues such as brain and lymphoid tissues. Immunohistochemistry reveals human Kell protein is localized to the Sertoli cells of the testis and the follicular dendritic cells of the spleen and tonsil. On erythrocytes, Kell is linked by a single disulfide bond to XK. The absence of XK, as occurs in the McLeod phenotype, is associated with a set of clinical symptoms that include nerve and muscle disorders and red cell acanthocytosis. The Molecular Weight of Kell is120 kDa. |
| Synonyms | CD238, Kpa antigen, Kpb antigen, Kpc antigen |
| Clonality | Monoclonal |
| Clone | BRIC 203 |
| Immunogen | Recombinant Kell Antigen |
| Isotype | Mouse IgG1 kappa light chain |
| Reactivity | Human |
| Form | Biotin-conjugate, in PBS buffer, pH 7.2 containing 0.1% sodium azide, 1% BSA |
| Storage | 2-8C, do not freeze |
| References | Marsh WL & Redman CM (1990) Transfusion 30, 158-167 (review) Redman CM et al. (1984) Transfusion 24, 176-178 Lee S et al. (1991) Proc. Natl. Acad. Sci. USA 88, 6353-6357 Anstee DJ et al (1992) In protein blood group antigens of the human red cell, chap. 8 170-181. ed. Agre P & Cartron JP. Johns Hopkins University Press. Parsons SF, et al. (1991) Transf. Med. 1 supp. 248 (abstract) Parsons SF et al. (1993) Transf. Med., 3: 137-142 |
| Supplier | ARP |
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