Anti-CD25 / IL2RA (Activated Lymphocyte Marker), Monoclonal Antibody
| Product Name | Anti-CD25 / IL2RA (Activated Lymphocyte Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 55kDa, identified as CD25 (Workshop IV; Code A27). CD25 is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkin_Ûªs disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R _ð ð chain, p75) and CD132 (common _ð ð chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This monoclonal antibody recognizes the epitope B, which is located at residue 3-104 of CD25 and can effectively block IL-2 binding to CD25. |
| Synonyms | IL2 Receptor alpha, IL2R alpha chain, IL2R, IL2R subunit alpha IL2RA, Interleukin-2 receptor subunit alpha, Ly43, p55, p55 chain, T Cell Growth Factor Receptor, TAC antigen, TCGFR |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 143-13 |
| Immunogen | Stimulated human leukocytes |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FA, FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3559 |
| Uniprot | P01589 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Knapp W. et al. Leucocyte typing IV, p. 408- 411 and p. 1080, Oxford University Press, Oxford 1989 |
| Supplier | ARP |
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