| Product Name | Anti-CD267 / TACI Monoclonal Antibody |
|---|---|
| Description | CD267 / TACI (Transmembrane Activator Calcium modulator and cyclophilin ligand Interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency. |
| Clone | 1A1 |
| Immunogen | CD267-transfected RBL cells |
| Isotype | IgG2a |
| Specificity |
The rat monoclonal antibody 1A1 recognizes CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells. HLDA 8 Workshop |
| Reactivity | Human |
| Applications | FC |
| Form | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage | Store at 2-8°C. Do not freeze. |
| Background | CD267 / TACI (Transmembrane Activator Calcium modulator and cyclophilin ligand Interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency. |
| Supplier | Exbio |
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