| Product Name | Anti-CD3 epsilon Antibody [OKT3] |
|---|---|
| Description | Mouse monoclonal [OKT3] antibody to CD3 epsilon. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | OKT3 |
| Conjugate | Unconjugated |
| Immunogen | Human PBMCs. |
| Isotype | IgG2a |
| Molecular Weight | 23 kDa |
| Target | CD3 epsilon |
| Specificity | This antibody recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly Intracytoplasmic. This MAb has been reported to have potent immunosuppressive properties in vivo and has been proven effective in the treatment of renal, heart and liver allograft rejection. |
| Reactivity | Human |
| Applications | IHC-Fr, FC, Functional Studies, IF |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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