| Product Name | Anti-CD30 Antibody [Ber-H8] (PE) |
|---|---|
| Description | Mouse monoclonal [Ber-H8] antibody to CD30 (PE). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Ber-H8 |
| Conjugate | PE |
| Isotype | IgG1 |
| Target | CD30 |
| Specificity | This antibody recognises CD30 also known as Ki-1 or TNFRSF8, a 120 kDa type I transmembrane glycoprotein receptor that belongs to the Tumor necrosis factor super family. CD30 is expressed by subpopulations of mitogen-stimulated T and B cell lymphoctyes and lymphoid neoplasms. CD30L, also known as TNSF8 or CD153 is the ligand of CD30. Once activated by its ligand, the receptor transduces the signal via the recruitment of TNFR-associated factor (TRAF) and TRAF associating proteins to form a signaling complex. This complex can subsequently activate NF?B and MAPK signaling pathways propagating anti-apoptotic/pro-survival responses. CD30 has been shown to be highly expressed in Hodgkin’s lymphoma and anaplastic large cell lymphoma. Some research has also indicated that CD30 is associated with a range of non-hematopoetic pathologies, including germ cell tumors and testicular embryonal carcinomas. This clone Ber-H8 has been used in flow cytometry experiments to measure CD30 surface expression levels on CD4+ cells upon treatment of cord blood with human heat shock protein 60. |
| Reactivity | Human |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide. |
| Concentration | Lot Specific |
| Purity | >95% (by SDS-PAGE). |
| Storage | Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. |
| Supplier | Antibodies.com |
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