Anti-CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker), Monoclonal Antibody
| Product Name | Anti-CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located between aa112-412. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This monoclonal antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45). |
| Synonyms | CD30L receptor, Cytokine receptor CD30, Ki-1 antigen, Lymphocyte activation antigen CD30, Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Ber-H2 |
| Immunogen | Co cell line established from a patient with Hodgkin s disease of T-cell lineage |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format. |
| Gene Id | 943 |
| Uniprot | P28908 |
| Storage | Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Schwarting R, Gerdes J, Durkop H, Falini B, Pileri S, Stein H. Ber-H2: A new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood 1989;74:1678-89. |
| Supplier | ARP |
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