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|Product Name||Anti-CD31 / PECAM-1 (Endothelial Cell Marker), Monoclonal Antibody|
|Description||CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 monoclonal antibody reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.|
|Applications||FC, IF, IHC, WB|
|FDA Status||For Research Use Only|
|Form||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Immunogen||Membrane preparation of a spleen from a patient with hairy cell leukemia|
|Intended Use||For Research Use Only|
|Reactivity||Human, Primate, Rabbit|
|References||Gratzinger D et. al. Am J Clin Pathol 131:264-278 (2009).|
|Storage||Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.|
|Synonyms||EndoCAM, PECA1, Platelet Endothelial Cell Adhesion Molecule 1, GPIIA'|
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