| Product Name | Anti-CD33 Antibody [SIGLEC3/3597] |
|---|---|
| Description | Mouse monoclonal [SIGLEC3/3597] antibody to CD33. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SIGLEC3/3597 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids a1-250) of human CD33 protein. The exact sequence is proprietary. |
| Isotype | IgG2b |
| Molecular Weight | 67 kDa |
| Target | CD33 |
| Specificity | Recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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