| Product Name | Anti-CD34 Antibody [ICO-115] |
|---|---|
| Description | Mouse monoclonal [ICO-115] antibody to CD34. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ICO-115 |
| Conjugate | Unconjugated |
| Immunogen | Blast cells of a chronic myeloid leukemia patient. |
| Isotype | IgG1 |
| Molecular Weight | 90-110 kDa |
| Target | CD34 |
| Specificity | This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels 85% of angiosarcoma and Kaposis sarcoma, but shows low specificity. |
| Reactivity | Human, Rat |
| Applications | ELISA, FC, IF |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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