| Product Name | Anti-CD34 Antibody [HPCA1/8333R] - BSA and Azide free |
|---|---|
| Description | Recombinant rabbit monoclonal [HPCA1/8333R] antibody to CD34. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | HPCA1/8333R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human HPCA1 protein. |
| Isotype | IgG |
| Molecular Weight | 41 kDa |
| Target | CD34 |
| Specificity | CD34 (also named myeloid progenitor cell antigen) is a heavily glycosylated type I transmembrane protein. There are two forms of the CD34 protein, resulting from alternative splicing. The functions of CD34 is largely unknown, but recent evidence suggests a role for CD34 in cell adhesion and inhibition of hematopoiesis. It is suggested that CD34 is a signaling molecule involved in maintenance of a phenotypically plastic state in undifferentiated cells. CD34 is found in most endothelia, expressed on the luminal surface and membrane processes interdigitating between endothelial cells, but is absent from large veins and arteries. CD34 is furthermore expressed in fibroblast-like dendritic cells in, e.g., portal tracts of the liver, Peyers patches, and in healing wounds. In smooth muscle cells, a variable CD34 staining is found. In tumor tissues, CD34 is detected in myeloid blasts in myelodysplastic syndrome and acute myeloid leukemia in most cases as well as lymphoblasts in most cases of B-acute lymphoblastic leukemia. Mature B- and T-cell lymphomas and leukemias are CD34 negative. The majority of vascular tumors, including hemangiosarcoma and Kaposi sarcoma are CD34positive. In a panel, CD34 staining is useful for the classification of myeloid and lymphoid neoplasms as well as spindle cell neoplasms (particularly identification of gastrointestinal stromal tumor and hemangiosarcoma). |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
