Anti-CD34 (Hematopoietic Stem Cell & Endothelial Marker), Monoclonal Antibody
| Product Name | Anti-CD34 (Hematopoietic Stem Cell & Endothelial Marker), Monoclonal Antibody |
|---|---|
| Description | This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi s sarcoma, but shows low specificity. |
| Synonyms | Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ICO-115 |
| Immunogen | Blast cells of a chronic myeloid leukemia patient |
| Isotype | IgG1, kappa |
| Reactivity | Human, Rat |
| Applications | FC, IF, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 947 |
| Uniprot | P28906 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Frolova, E., Baryshnikov A.Y., Frenkel M. et al., Monoclonal antibody ICO-115 to human CD34 antigen. Herald of the Cancer Research Center of RAMS. Suppl, p. 10-12, 1994.Kishimoto et al., Leucocyte typing Gariand Publishing. 1997. |
| Supplier | ARP |
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