Anti-CD34 (Hematopoietic Stem Cell & Endothelial Marker), Monoclonal Antibody
| Product Name | Anti-CD34 (Hematopoietic Stem Cell & Endothelial Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into_three main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain._CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi s sarcoma, but with a lower specificity. |
| Synonyms | Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | QBEnd/10 |
| Immunogen | Detergent solubilized vesicular suspension prepared from human term placenta |
| Isotype | IgG1, kappa |
| Reactivity | Bovine, Canine, Human, Primate, Sheep |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml. |
| Gene Id | 947 |
| Uniprot | P28906 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required. |
| References | Ramani P; Bradley NJ; Fletcher CD. QBEND/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology, 1990, 17:237-42. |
| Supplier | ARP |
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