Anti-CD36 (Platelet & Microvessel Marker), Monoclonal Antibody
| Product Name | Anti-CD36 (Platelet & Microvessel Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 80kDa-90kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. |
| Synonyms | Adipocyte membrane protein, CHDS7, Collagen receptor, platelet, fatty acid translocase (FAT), Fatty acid transport protein, glycoprotein iiib (GP IIIb), PAS IV, PAS-4, pas4 protein, platelet collagen receptor, Platelet glycoprotein 4, scarb3, Scavenger receptor class B member 3, thrombospondin receptor |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | GPIIIb/654 |
| Immunogen | Recombinant human GPIIIb protein |
| Isotype | IgG2a, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 948 |
| Uniprot | P16671 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Kishimoto T. et al., eds. Leukocyte Typing VI, p636-643 and p1136-1137, Garland Publishing, Inc, New York and London, 1997.Greenwalt DE Ikeda H,Tandon NN,Jamieson GA Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. Blood 1992 80:1105Savill J, et al. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest. 1992;90(4):1513-1522. Stomski FC et. al. Experimental Cell Research, 1992, 198(1):85-92.Biggs BA et. al. Journal of Experimental Medicine, 1990, 171(6):1883-1892 |
| Supplier | ARP |
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