| Product Name | Anti-CD4 Antibody [CD4/8203R] |
|---|---|
| Description | Recombinant rabbit monoclonal [CD4/8203R] antibody to CD4. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | CD4/8203R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 200-400) of human CD4 protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 55 kDa |
| Target | CD4 |
| Specificity | Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4+/CD8-. Anti-CD4 is used in the immunohistochemical staining of lymphoproliferative disorders to evaluate tumors with CD4 aberrant expression. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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