Anti-CD4 (T-Helper/Inducer Cell Marker), Monoclonal Antibody
| Product Name | Anti-CD4 (T-Helper/Inducer Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 55kDa, identified as CD4. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified._ |
| Synonyms | L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, p55, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C4/206 |
| Immunogen | Recombinant human CD4 protein |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 920 |
| Uniprot | P01730 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Janeway, C.A., Jr. 1992. The T cell receptor as a multicomponent signaling machine: CD4/CD8 co-receptors and CD45 in T cell activation. Annu. Rev. Immunol. 10: 645-674. Arthos, J., et al. 1989. Identification of the residues in human CD4 critical for the binding of HIV. Cell 57: 469-481 |
| Supplier | ARP |
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