Anti-CD4 (T-Helper/Inducer Cell Marker), Monoclonal Antibody
| Product Name | Anti-CD4 (T-Helper/Inducer Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified._This monoclonal antibody was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens. |
| Synonyms | L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, p55, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EDU-2 |
| Immunogen | Stimulated human leukocytes |
| Isotype | IgG2a, kappa |
| Reactivity | Human, Primate |
| Applications | FA, FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 920 |
| Uniprot | P01730 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Reinberz EL et al. eds. Leykcocyte Typing II, Springer-Verlag, Berlin, 1985. Knapp W. et. al. (eds) Leukocyte Typing IV, p314-330, Oxford University Press, Oxford, 1989.Sattentau QJ, et al. The CD4 antigen: physiological ligand and HIV receptor. Cell. 1988, 52(5):631-633. Gaubin M, et al. Molecular basis of T lymphocyte CD4 antigen functions. Eur J Clin Chem Clin Biochem. 1996, 34(9):723-728.Mazerolles F, et al. Down regulation of T-cell adhesion by CD4. Hum Immunol. 1991, 31(1):40-6 |
| Supplier | ARP |
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