Anti-CD41a / Integrin alpha2b (Platelet Marker), Monoclonal Antibody
| Product Name | Anti-CD41a / Integrin alpha2b (Platelet Marker), Monoclonal Antibody |
|---|---|
| Description | Reacts with a calcium-dependent complex of CD41/CD61, a dimer of 90kDa and 140kDa present on the membrane of normal platelets and megakaryocytes. CD41/CD61 is also known as platelet glycoprotein GPIIb/GPIIIa or integrin IIa/3. This complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. |
| Synonyms | BDPLT16, BDPLT2, GPalpha IIb, GT, HPA3, Integrin alpha IIb, ITGA2B, ITGAB, platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex |
| Host | Mouse |
| Clone | ITGA2B/1036 |
| Immunogen | Recombinant full-length human Integrin alpha IIb protein |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3674 |
| Uniprot | P08514 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References |
McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995. Smith JW et al. Interaction of integrins _v_3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990, 265(21):12267-12271. Du XP et al. Ligands activate integrin _IIb/_3 (platelet GPIIb-IIIa). Cell 1991, 65(3):409-416. Law DA et al. Outside-in integrin signal transduction. _IIb/_3-(GP IIb/IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996, 271(18):10811-10815. Moroi M and Jung SM. Integrin-mediated platelet adhesion. Front Biosci 1998, 3:D719-728 |
| Supplier | ARP |
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