| Product Name | Anti-CD41/CD61 Monoclonal Antibody, Biotin |
|---|---|
| Description | Mouse monoclonal antibody to human CD41/CD61 Biotin conjugate. The integrin alpha IIb chain interacts with the integrin beta 3 subunit (CD61) to form the platelet glycoprotein complex, GpIIb/IIIa. It is expressed on platelets and megakaryocytes. The CD41/CD61 complex appears early in megakaryocyte maturation. Ligands for the GpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The GpIIb/IIIa complex is the major integrin on platelets and is important for clot retraction, platelet adhesion and aggregation. |
| Synonyms | CD41/CD61, platelet glycoprotein complex, GpIIb/IIIa |
| Clonality | Monoclonal |
| Clone | PAB-1 |
| Immunogen | CD41/CD61 heterodimer protein. |
| Isotype | Mouse IgG1 kappa light chain |
| Reactivity | Human |
| Form | Biotin-conjugate, in PBS buffer, pH 7.2 containing 0.1% sodium azide, 1% BSA |
| Storage | 2-8C, do not freeze |
| References | 1. Sun QH, Newman PJ. CD guide. CD41. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 1139. 2. Vinci G, Tabilio A, Deschamps JF, van Haeke D, Henri A, Guichard J, et al. Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol 1984;56:589-605. 3. Campbell K, Rishi K, Howkins G, Gilby D, Mushens R, Ghevaert C, Metcalfe P, Ouwehand W, Lucas G (2007). A modified rapid monoclonal antibody-specific immobilisation of platelet antigen assay for the detection of human platelet antigens (HPA) antibodies: a multicentre evaluation. Vox Sanguinis, 93, 289-297. |
| Supplier | ARP |
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