| Product Name | Anti-CD44 Antibody [YKIX337.8.7] |
|---|---|
| Description | Rat monoclonal [YKIX337.8.7] antibody to CD44. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | YKIX337.8.7 |
| Conjugate | Unconjugated |
| Immunogen | Concanavilin A activated Canine T cells. |
| Isotype | IgG2a |
| Target | CD44 |
| Specificity | This antibody recognises canine CD44, also known as H-CAM, a single-pass type 1 membrane of approximately 90 kDa expressed by most leucocytes and epithelial cells. CD44 expression is markedly increased upon cell activation. CD44 is involved in cell-cell, cell adhesion and cell migration and is the principal cellular receptor for hyaluronate via it's LINK domain, additionally CD44 interacts with other ligands including collagens and metalloproteinases. Altered CD44 expression is detected in many forms of invasive and metastatic cancer, CD44 expression has been observed on canine mammary and melanocytic tumors. |
| Reactivity | Canine, Mammal |
| Applications | IHC-Fr, FC |
| Working Dilutions | Flow Cytometry: 1:10 - 1:20, Use 10µl of the suggested working dilution to label 106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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