Anti-CD46 (Membrane Cofactor Protein), Monoclonal Antibody
| Product Name | Anti-CD46 (Membrane Cofactor Protein), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This monoclonal antibody can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells. |
| Synonyms | AHUS2, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen, Trophoblast lymphocyte cross reactive antigen |
| Host | Mouse |
| Clone | 197-2B1 |
| Immunogen | Stimulated human leukocytes |
| Isotype | IgG2a, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4179 |
| Uniprot | P15529 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References |
Kishimoto T. et al., eds. Leukocyte Typing VI, p506-509 and p1145-1146, Garland Publishing, Inc., New York and London, 1997. Liszewski MK and Atkinson JP. Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complement. J Immunol 1996, 156:4415-4421. Blixenkrone-Moller M, et al. Role of CD46 in measles virus infection in CD46 transgenic mice. Virology 1998, 249(2):238-248 Okada N et al. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A 1995, 92(7):2489-2493. Kallstrom H et al. Cell signaling by the type IV pili of pathogenic Neisseria. J Biol Chem 1998, 273(34):21777-8 |
| Supplier | ARP |
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