Anti-CD47 / IAP (Integrin Associated Protein), Monoclonal Antibody
Product Name | Anti-CD47 / IAP (Integrin Associated Protein), Monoclonal Antibody |
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Description | This antibody reacts with Ig domain of CD47 protein. It has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus._ CD47 may play a role in membrane transport and/or integrin dependent signal transduction._ |
Synonyms | Antigenic Surface Determinant Protein OA3, IAP, Integrin Associated Protein, Integrin Associated Signal Transducer, MER6, OA3, Protein MER6, Rh Related Antigen |
Host | Mouse |
Clonality | Monoclonal |
Clone | B6H12.2 |
Immunogen | Intact CD47 purified from placenta |
Isotype | IgG1, kappa |
Reactivity | Human, Mouse |
Applications | FA, FC, IF, IHC |
Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
Gene Id | 961 |
Uniprot | Q08722 |
Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
References | Edris B et. al. Proc Natl Acad Sci USA 109:6656-61 (2012). Willingham SB et. al. Proc Natl Acad Sci USA 109:6662-7 (2012) |
Supplier | ARP |
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