| Product Name | Anti-CD49b/CD29 Monoclonal Antibody, APC |
|---|---|
| Description | Mouse monoclonal antibody to human CD49b/CD29-Affinity purified. The CD49b (GpIa) protein is the alpha subunit of the integrin GpIa/IIa heterodimer (CD49b/CD29). Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain and are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. On platelets, the GpIa/IIa complex functions primarily as a ligand for collagen. |
| Synonyms | CD49b/CD29 antigen, GpIa protein, alpha subunit of the integrin GpIa/IIa heterodimer |
| Clonality | Monoclonal |
| Clone | P-16 |
| Immunogen | P-16 was made in response to immunisation with Glanzmann s platelets (lacking GpIIb/IIIa). |
| Isotype | Mouse IgG1 kappa light chain |
| Reactivity | Human |
| Form | APC-conjugate, in PBS buffer, pH 7.2 containing 0.1% sodium azide, 1% BSA |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Campbell K, Rishi K, Howkins G, Gilby D, Mushens R, Ghevaert C, Metcalfe P, Ouwehand W, Lucas G (2007). A modified rapid monoclonal antibody-specific immobilisation of platelet antigen assay for the detection of human platelet antigens (HPA) antibodies: a multicentre evaluation. Vox Sanguinis, 93, 289-297 |
| Supplier | ARP |
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