Anti-CD56 / NCAM1 / NKH1 (Neuronal Cell Marker), Monoclonal Antibody
| Product Name | Anti-CD56 / NCAM1 / NKH1 (Neuronal Cell Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas. |
| Synonyms | NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPM489 |
| Immunogen | Membrane preparation of a small cell lung carcinoma |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4684 |
| Uniprot | P13591 & P13592 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Gerardy-Schahn R; et. al. Int Journal of Cancer. Supplement, 1994, 8:38-42.Michalides R; et. al. International Journal of Cancer. Supplement, 1994, 8:34-7.K. Moolenaar et al.Cancer Research 50, 1102-1106, 1990Schol DJ; et. al. Int J Cancer. Supplement, 1988, 2:34-4 |
| Supplier | ARP |
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