| Product Name | Anti-CD57 Monoclonal Antibody |
|---|---|
| Description | CD57, also known as HNK1 or Leu7, is a sulphated trisaccharide (3-O-sulfoglucuronic acid beta1-3 Gal beta1-4 GlcNAc) attached to several glycoproteins, including CD56, myelin glycoprotein PO, and neural cell adhesion molecule L1, as well as on glycolipids and chondroitin sulphate proteoglycans in the nervous system. It serves as a NK cell marker and it is expressed on well differentiated prostate cancers and uveal and cutaneous melanoma. CD57+ T cells are implicated as suppressors of T-cell responses. The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests. |
| Clone | TB01 |
| Immunogen | A pool of neuroblastoma cell lines |
| Isotype | IgM |
| Specificity |
The mouse monoclonal antibody TB01 recognizes CD57, a carbohydrate antigen present mainly on NK cells, NK T cells, and in neural tissue. HLDA VI; WS Code NK16 |
| Reactivity | Human |
| Applications | FC, ICC, IHC, WB |
| Form | The reagent is provided in stabilizing Tris buffered saline (TBS) solution containing 15mM sodium azide. |
| Background | CD57, also known as HNK1 or Leu7, is a sulphated trisaccharide (3-O-sulfoglucuronic acid beta1-3 Gal beta1-4 GlcNAc) attached to several glycoproteins, including CD56, myelin glycoprotein PO, and neural cell adhesion molecule L1, as well as on glycolipids and chondroitin sulphate proteoglycans in the nervous system. It serves as a NK cell marker and it is expressed on well differentiated prostate cancers and uveal and cutaneous melanoma. CD57+ T cells are implicated as suppressors of T-cell responses. |
| Supplier | Exbio |
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