| Product Name | Anti-CD58 Antibody [MEM-63] (APC) |
|---|---|
| Description | Mouse monoclonal [MEM-63] antibody to CD58 (APC). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MEM-63 |
| Conjugate | APC |
| Isotype | IgG1 |
| Target | CD58 |
| Specificity | This antibody recognises human CD58, also known as LFA-3. CD58 is a membrane glycoprotein of ~55-70 kDa. It occurs in two forms, one transmembrane with a cytoplasmic domain, the other form anchored in the membrane via a glycosylphosphatidylinositol tail. The complete amino acid sequence of both forms has been deduced from cDNA. CD58 is a heavily N-glycosylated cell adhesion molecule which plays a critical role in facilitation of antigen specific recognition through interaction with CD2 on T lymphocytes. CD58 has a wide tissue distribution, being present on erythrocytes, platelets, monocytes, a subset of lymphocytes, bone marrow cells, epithelium and endothelial cells. There are approximately 5,000 CD58 molecules on each erythrocyte. There is reduced expression of CD58 on haemopoietic cells in individuals with paroxysmal nocturnal haemoglobinuria. |
| Reactivity | Human |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in TRIS Buffered Saline with 0.09% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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