| Product Name | Anti-CD6, Monoclonal Antibody |
|---|---|
| Description | CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular ðscavenger receptor cysteine-richð (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease. |
| Synonyms | T12, TP120 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPV-L14 |
| Immunogen | CD8+ cytotoxic T-cell clone |
| Isotype | IgG1 |
| Reactivity | Human, Mouse |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 923 |
| Uniprot | P30203 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Kamoun et al., J. Immunol. 127, 987, 1981Reinherz et al., Proc. Nat. Acad. Sci. 79, 6047, 1982Yssel, H., de Vries, J.E., Borst, J. and Spits, H. Distribution and functional analysis of a 120-130 kDa T cell surface antigen. Cell. Immunol. 105: 161-173, 1987.Bazil, V et. al. 1989. Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102. Folia. Biol. 35:289-297 |
| Supplier | ARP |
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