| Product Name | Anti-CD65 Monoclonal Antibody |
|---|---|
| Description | CD65 is a fucosylated carbohydrate antigen (ceramide-dodecasaccharide, type II fucoganglioside), which serves as a ligand for CD62E (E-selectin). Its structure is Gal beta1-4 GlcNAc beta1-3 Gal beta1-4 GlcNAc (3-1 Fuc alpha) beta1-3 ceramide. Unlike CD65s, the CD65 antigen does not contain terminal sialic acid, the rest of their structure is identical. CD65 is expressed on granulocytes and monocytes and participates in cell adhesion. It has been reported as important for extravascular infiltration of acute monocytic leukemia cells. The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension.The content of a vial (1 ml) is sufficient for 100 tests. |
| Clone | VIM8 |
| Immunogen | THP-1 cell line |
| Isotype | IgM |
| Specificity |
The mouse monoclonal antibody VIM8 recognizes human CD65, an asialo-fucoganglioside expressed on peripheral blood granulocytes (highly) and monocytes (weakly). HLDA II; WS Code M 27 HLDA III; WS Code M 261 HLDA IV; WS Code M 23 HLDA V; WS Code MA095, MA096 HLDA VI; WS Code MR12 |
| Reactivity | Human |
| Applications | FC |
| Form | The reagent is provided in stabilizing Tris buffered saline (TBS) solution containing 15mM sodium azide. |
| Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
| Background | CD65 is a fucosylated carbohydrate antigen (ceramide-dodecasaccharide, type II fucoganglioside), which serves as a ligand for CD62E (E-selectin). Its structure is Gal beta1-4 GlcNAc beta1-3 Gal beta1-4 GlcNAc (3-1 Fuc alpha) beta1-3 ceramide. Unlike CD65s, the CD65 antigen does not contain terminal sialic acid, the rest of their structure is identical. CD65 is expressed on granulocytes and monocytes and participates in cell adhesion. It has been reported as important for extravascular infiltration of acute monocytic leukemia cells. |
| Supplier | Exbio |
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