| Product Name | Anti-CD7 (T-Cell Leukemia Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 40kDa, identified as CD7 (Workshop IV; Code T165). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. |
| Synonyms | GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HuLy-m2 |
| Immunogen | Human thymocytes |
| Isotype | IgG2a, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 924 |
| Uniprot | P09564 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Sandrin et al. In Leukocyte Typing III, McMichael AJ (ed), Oxford University Press, Oxford, 216219 (1987).Knapp W et al. eds. Leukocyte typing IV, p341, Oxford University Press, Oxford, 1989.Miwa H, et al biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. 1996;21:239-44. Rabinowich H, et al. J. Immunol. 1994 153(8):3504-3513.Emara M, et al. A human suppressor T-cell factor that inhibits T-cell replication by interaction with the IgM-Fc receptor (CD7). Hum Immunol. 1989;25(2):87-102.Thurlow PJ, A monoclonal antibody detecting a new human T cell antigen, HuLy-m2. Transplantation 1984, 38(2):143-147.Saxena A, et al. Biologic and clinical significance of CD7 expression in acute myeloid leukemia. Am J Hematol. 1998;58(4):278-84 |
| Supplier | ARP |
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