| Product Name | Anti-CD80 Antibody [C80/3544] |
|---|---|
| Description | Mouse monoclonal [C80/3544] antibody to CD80. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C80/3544 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 35-142, of human CD80 protein. The exact sequence is proprietary. |
| Isotype | IgG2b |
| Molecular Weight | 60 kDa |
| Target | CD80 |
| Specificity | T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell. |
| Reactivity | Human |
| Applications | ELISA, IHC-P |
| Working Dilutions | IHC-P: 2-4 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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