Anti-CD8A (Cytotoxic / Suppressor T-Cell Marker), Monoclonal Antibody
| Product Name | Anti-CD8A (Cytotoxic / Suppressor T-Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 32kDa, identified as CD8a (also known as CD8 chain, T cell co-receptor, Leu2, and T8). CD8 molecule consists of two chains, termed and chain, which are expressed as a disulphide-linked heterodimer or as an homodimer. CD8 is expressed on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells. The majority of CD8+ T-cells expresses CD8 as heterodimer. Some subpopulation of CD8+ T cells as well as NK cells may express homodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 chain (but not chain). The cytoplasmic domain of CD8 associates with p56lck tyrosine kinase. |
| Synonyms | CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | RIV11 |
| Immunogen | Human peripheral lymphocytes |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 925 |
| Uniprot | P01732 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989 Parnes JR, CD4 and CD8 in T cell lineage commitment: alterations induced by expression of a CD8/CD4 chimeric transgene. Semin Immunol 1994, 6:221-229. Delon J. et al. CD8 expression allows T cell signaling by monomeric peptide-MHC complexes. Immunity 1998, 9(4):467-73 Akimoto H, et al. Binding of HIV-2 envelope glycoprotein to CD8 molecules and related chemokine production. Immunology 1998, 95(2):214-218 Leahy DJ. A structural view of CD4 and CD8. FASEB J. 1995,9(1):17-25. Jonker M et al. Side effects and immunogenicity of murine lymphocyte-specific monoclonal antibodies in subhuman primates. Transplantation 1988, 45(4):677-682 |
| Supplier | ARP |
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