| Product Name | Anti-CD95 / FAS / TNFRSF6, Monoclonal Antibody |
|---|---|
| Description | monoclonal antibody B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes. |
| Synonyms | ALPS1A, Apoptosis APO1 antigen 1, Apoptosis-mediating surface antigen FAS, APT1, Delta Fas/APO1/CD95, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas cell surface death receptor, FAS1, FASL receptor, FASLG receptor, FASTM, Surface antigen APO1, TNF receptor superfamily member 6 (TNFR6), Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B-R18 |
| Immunogen | Recombinant human CD95 protein |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FA, FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 355 |
| Uniprot | P25445 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Sasaki et al. Br J Urol 81: 852, 1998.Sugihara et al. Anticancer Res 17: 3861, 1997.Kondo et al. J Pathol 183: 75, 1997 |
| Supplier | ARP |
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