| Product Name | Anti-CD98 Antibody [H202-529.4.1.4] |
|---|---|
| Description | Rat monoclonal [H202-529.4.1.4] antibody to CD98. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | H202-529.4.1.4 |
| Conjugate | Unconjugated |
| Immunogen | Thymic epithelial cells from mouse. |
| Isotype | IgG1 |
| Target | CD98 |
| Specificity | This antibody recognises mouse CD98, also known as 4F2 and SLC3A2. CD98 is a type II transmembrane glycoprotein which associates with members of the L-type amino transporter family to form a heterodimeric complex.CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis. |
| Reactivity | Mouse |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat for 0.25 mg, 1:20 for 0.1 mg - 1:50 for 0.25 mg, 1:200 for 0.1 mg, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl. |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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