Anti-CD99 / MIC2 (Ewing's Sarcoma Marker), Monoclonal Antibody
| Product Name | Anti-CD99 / MIC2 (Ewing's Sarcoma Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a sialoglycoprotein of 27-32kDa, identified as CD99, or MIC2 gene product, or E2 antigen. MIC2 gene is located in the pseudo-autosomal region of the human X and Y chromosome. MIC2 gene encodes two distinct proteins, which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32kDa (p30/32)._Although its function is not fully understood, CD99 is implicated in various cellular processes including homotypic aggregation of T cells, upregulation of T cell receptor and MHS molecules, apoptosis of immature thymocytes and leukocyte diapedesis._CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. Most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells express this antigen. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing_Ûªs sarcoma cells and primitive peripheral neuroectodermal tumors. |
| Synonyms | 12E7, E2 antigen, MIC 2X, MIC 2Y, MIC2, Protein MIC2, Surface antigen MIC2, T-cell surface glycoprotein E2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 12E7 + MIC2/877 |
| Immunogen | Human acute lymphocytic leukemia T-cells (12E7); Recombinant human MIC2 protein (MIC2/877) |
| Isotype | IgG's |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format. |
| Gene Id | 4267 |
| Uniprot | P14209 |
| Storage | Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Levy R, Dilley J, Fox RI, Warnke R. A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies. PNAS USA 1979;76(12):6552- |
| Supplier | ARP |
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