| Product Name | Anti-CDK4 (clone AT6D10) |
|---|---|
| Description | Cyclin-dependent kinase 4, also known as CDK4, belongs to the cyclin-dependent kinases (CDK) family. CDKs are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDK4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin up-regulates CDK4 activity, whereas binding to the CDK inhibitor p16 down-regulates CDK4 activity. |
| Synonyms | Cyclin-dependent kinase 4, CMM3, PSK-J3 |
| Host | Mouse |
| Clone | Anti-human CDK4 mAb, clone AT6D10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CDK4 protein. |
| Immunogen | Recombinant human CDK4 (1-303aa) purified from E. coli |
| Isotype | K,IgG2a |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Coleman KG, et al. (1997). J. Biol. Chem. 272 (30): 18869€“74.Li J, Melvin WS, Tsai MD, Muscarella P (2004). Biochemistry 43 (14): 4394€“9.Dai K, Kobayashi R, Beach D (1996). J. Biol. Chem. 271 (36): 22030€“4. |
| Supplier | ARP |
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