| Product Name | Anti-Cdk4 (cyclin-dependent kinase 4) Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. Mouse Monoclonal Antibody to Cdk4 (cyclin-dependent kinase 4) |
| Synonyms | CMM3, PSK-J3 |
| Clonality | Monoclonal |
| Clone | DCS-35 |
| Immunogen | Human Recombinant full-length cdk4 polypeptide |
| Isotype | IgG1 |
| Specificity | DCS-35 reacts specifically with cdk-4 protein present predominantly in G1 phase of cell cycle; it does not cross react with cyclins. especially suitable for immunoprecipitation. Mab DCS-35 precipitates the cdk4/cyclin complex. |
| Reactivity | Human, Mouse, Porcine, Rat |
| Applications | IP, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Lukas C et al. (1999) Hybridoma 18: 225-234 |
| Background | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. |
| Supplier | ARP |
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