| Product Name | Anti-Cdk6 (cyclin-dependent kinase 6) Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mouse Monoclonal Antibody to Cdk6 (cyclin-dependent kinase 6). Cdk6 is highly expressed in some lymphoid tumor and sarcoma cell lines (ML-1 and U-2-OS resp.). |
| Synonyms | PLSTIRE |
| Clonality | Monoclonal |
| Clone | DCS-83 |
| Immunogen | Human Recombinant full-length cdk6 polypeptide |
| Isotype | IgG1 |
| Specificity | DCS-83 reacts specifically with Cdk6 kinase, which can substitute for Cdk4. |
| Reactivity | Human |
| Applications | IHC, IP, WB |
| Form | Affinity purified, 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4 |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| Background | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| Supplier | ARP |
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