Anti-CDw17 (Lactosylceramide or LacCer), Monoclonal Antibody
| Product Name | Anti-CDw17 (Lactosylceramide or LacCer), Monoclonal Antibody |
|---|---|
| Description | CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor _ ð (TNF_ ð)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization. |
| Synonyms | Lactosylceramide, LacCer, ð-D-galactosyl-(1-4)-ð-D-glucosyl-(1-1')-ceramide, CDw17 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HuLy-m13 |
| Immunogen | _-2 Microglobulin associated proteins from a detergent lysate of human PBL |
| Isotype | IgM |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Lovering, K.E. Characterisation of the Tcell surface by monoclonal antibodies. PhD thesis, University of Melbourne, 1985.Knapp W. Leukocyte Typing IV, Oxford Univ. Press, pp. 810811, 1989. Also data on M119, pp 861, 874, 877 879, 897, 907, 923, 925 |
| Supplier | ARP |
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