| Product Name | Anti-CEACAM1 + CEACAM3 + CEACAM6 Antibody [YTH71.3] |
|---|---|
| Description | Rat monoclonal [YTH71.3] antibody to CEACAM1 + CEACAM3 + CEACAM6 . |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | YTH71.3 |
| Conjugate | Unconjugated |
| Immunogen | Human lymphocytes. |
| Isotype | IgG2a |
| Target | CEACAM1 + CEACAM3 + CEACAM6 |
| Specificity | This antibody recognises 3 members of the human CD66 family, namely CD66a, also known as Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1 or CEACAM1. Clone YTH71.3 also recognises CD66c, known as Carcinoembryonic antigen-related cell adhesion molecule 6 or Non-specific crossreacting antigen. In addition the clone also recognises CD66d which in turn is also known as Carcinoembryonic antigen-related cell adhesion molecule 3 or CGM1. CD66 family members are single pass, type 1 membrane glycoproteins bearing a single V-type Ig-like domain and a varying number of C2-type Ig-like domains. Clone YTH71.3 recognises epitopes in the N-terminal domain of these CD66 family members.CD66 members are expressed by human neutrophils and cells of the colon where it is down regulated in some cases of colon carcinoma. CD66a is also expressed in the human alveolar adenocarcinoma cell line A549 and may play a role in Moraxella catarrhalis induced apoptosis of pulmonary epithlial cells in diseases including COPD and emphysema (N'Guessan et al. 2007). |
| Reactivity | Human, Primate |
| Applications | IHC-Fr, FC, IHC-P |
| Working Dilutions | IHC-P: 10 µg/ml, Use 10µl of the suggested working dilution to label 1 x 106 cells in 100µl. |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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