Anti-CELA3B / ELA3B (Pancreatic Function Marker), Monoclonal Antibody
| Product Name | Anti-CELA3B / ELA3B (Pancreatic Function Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody recognizes a protein of ~17kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. |
| Synonyms | Chymotrypsin like elastase family member 3B (CELA3B), ELA3B, Elastase IIIB, Protease E |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CELA3B/1218 |
| Immunogen | Recombinant human CELA3B protein |
| Isotype | IgG, kappa |
| Reactivity | Human |
| Applications | ELISA, FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 23436 |
| Uniprot | P08861 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Shirasu, Y., et al. 1988. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. J. Biochem. 104:259-264.Tani, T., et al. 1988. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. J. Biol. Chem. 263: 1231-1239.Shimada, S., et al. 2002. Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells. Int. J. Mol. Med. 10: 599-603 |
| Supplier | ARP |
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