| Product Name | Anti-CFTR Antibody [CFTR/1342] |
|---|---|
| Description | Mouse monoclonal [CFTR/1342] antibody to CFTR. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CFTR/1342 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment of human CFTR protein. |
| Isotype | IgG2a |
| Molecular Weight | 165-170 kDa |
| Target | CFTR |
| Specificity | This antibody recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. |
| Reactivity | Human, Mouse |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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