| Product Name | Anti-Chromogranin A Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. LK2H10 represents an excellent marker for most neuroendocrine, neuronal and adrenal tumors. |
| Synonyms | CGA |
| Clonality | Monoclonal |
| Clone | LK2H10 |
| Immunogen | Human Phaeochromocytoma |
| Isotype | IgG1k |
| Specificity | Tumors specifically detected: Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas. Neuroendocrine tumors of epithelial origin: Pancreatic isletcell carcinoma, broncial and gastrointestinal carcinoids, gastroadenomas from pituitary, middle ear and parathyroid; some argyrophylic carcinoma of the breast and argyrophilic cells in Brenner tumors. Merkel cell tumors of skin and small cell lung carcinoma react weakly. |
| Reactivity | Human, Porcine, Primate, Rabbit, Rat |
| Form | Stabilized Ascites |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Aguirre,P.et al. (1986) Int. J. Gynecol. Pathol. 5: 223 DeStephano, D.B.et al. (1984) Am. J. Pathol. 116: 464Harlow, E. et al. (1988) Antibodies: A laboratory manual, p. 359, Cold Spring Laboratory, New YorkLloyd, R. V., and Wilson, B.S. (1983) Science 222: 628McNutt, M.A.& John, W. Bolen (1985) Am. J. Clin. Pathol. 84: 541Pietroletti, R.et a. (1986) Gut 27: 838Wiedenmann, B.et al. (1988) Gastroenterology 95: 1364Wilson, B.S. et al. (1984) Am. J. Pathol. 115: 458 |
| Background | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. |
| Supplier | ARP |
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