| Product Name | Anti-CHUK Polyclonal Antibody |
|---|---|
| Description | The NF-_B/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory I_B proteins. Most agents that activate NF-_B do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of I_B. The key regulatory step in this pathway involves activation of a high molecular weight I_B kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK_ and IKK_ serve as the catalytic subunits of the kinase and IKK_ serves as the regulatory subunit . Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK_ (Ser176 and Ser180 in IKK_), which causes conformational changes, resulting in kinase activation. |
| Host | Rabbit |
| Immunogen | A synthetic peptide of human CHUK |
| Isotype | IgG |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| Storage | Store at -20C or -80C. Avoid repeated freeze/thaw cycles. |
| Background | The NF-_B/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory I_B proteins. Most agents that activate NF-_B do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of I_B. The key regulatory step in this pathway involves activation of a high molecular weight I_B kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK_ and IKK_ serve as the catalytic subunits of the kinase and IKK_ serves as the regulatory subunit . Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK_ (Ser176 and Ser180 in IKK_), which causes conformational changes, resulting in kinase activation. |
| Supplier | Cusabio |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
