| Product Name | Anti-CMBL (clone AT2B11) |
|---|---|
| Description | CMBL(carboxymethylenebutenolidase homolog) is a 245 amino acid cytosolic protein and cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL is the human homolog of Pseudomonas dienelactone hydrolase, a protein that participates in the bacterial halocatechol degradation pathway. That is ubiquitously expressed with high expression in liver, colon, kidney and small intestine, where it acts as a bioactivating enzyme for a prodrug type angiotensin II type 1 receptor antagonist known as olmesartan medoxomil. CMBL is inhibited by p-chloromercuribenzoate (PCMB). |
| Synonyms | Carboxymethylenebutenolidase homolog, |
| Host | Mouse |
| Clone | AT2B11. Anti-human CMBL mAb, clone AT2B11, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CMBL protein. |
| Immunogen | Recombinant human CMBL (1-245aa) purified from E. coli |
| Isotype | K,IgG2a |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Ishizuka T, et al. (Apr 2010). J Biol Chem. 16;285(16):11892-902Yang X, et al. (Mar 2010). J Proteome Res. 5;9(3):1402-15. |
| Supplier | ARP |
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