| Product Name | Anti-CNOT10 Antibody [PCRP-CNOT10-1D5] |
|---|---|
| Description | Mouse monoclonal [PCRP-CNOT10-1D5] antibody to CNOT10. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-CNOT10-1D5 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human CNOT10 protein. |
| Isotype | IgG2c |
| Molecular Weight | 82.31 kDa |
| Target | CNOT10 |
| Specificity | CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. |
| Reactivity | Human |
| Applications | ELISA, FC, IF, IP, WB |
| Working Dilutions | IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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