| Product Name | Anti-Collagen I Antibody [NFI/20] |
|---|---|
| Description | Mouse monoclonal [NFI/20] antibody to Collagen I. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NFI/20 |
| Conjugate | Unconjugated |
| Immunogen | Human Collagen type I from placenta. |
| Isotype | IgG1 |
| Target | Collagen I |
| Specificity | This antibody recognises human Collagen I composed of trimers consisting of 2 Collagen alpha-2(I) chains and a single Collagen alpha-1(I) chain forming collagen fibrils in ligaments, tendon, skin and bone where they become mineralized by calcium hydroxyapatite. Mouse anti human Collagen I, clone NFI/20 does not cross-react with collagen types II, III and IV. Collagen is located in the extracellular matrix of connective tissues. It is part of the interacting network of proteoglycans and proteins that provides a structural framework for both soft and calcified connective tissues.Mutations in the encoding gene are associated with osteogenesis imperfecta , Ehlers Danlos syndrome and idiopathic juvenile osteoporosis. Defective processing of collagen I by lysyl hydroxylase has also been implicated in Ehlers Danlos syndrome , |
| Reactivity | Human |
| Applications | IHC-Fr, ELISA |
| Working Dilutions | ELISA: 1:1,000, IHC-Fr: 1:20 |
| Form | Lyophilized |
| Diluent Buffer | Supplied in 0.1M Sodium Chloride with 0.01M Sodium Phosphate, 0.01M Sodium Borate, 1% Dextran, and 1% Mannitol. |
| Concentration | Reconstitution dependent. |
| Storage | Lyophilized: Store at 4°C. Reconstituted: Store at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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