| Product Name | Anti-Complement C3a Monoclonal Antibody |
|---|---|
| Description | Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. Mouse Monoclonal antibody to Complement C3a. Detection of C3 deposits in tissue, cells, micro-organisms and immune complexes. It should be used with positive control anti-C3b (H11/H206). Non-activated, absorbed C3 contains the C3a determinant, whereas activated C3 is negative with H 13. Polypeptide reacting: C3a-determinant on C3 alpha-chain |
| Synonyms | ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1 |
| Clonality | Monoclonal |
| Clone | H 13 |
| Immunogen | Human complement component C3 |
| Isotype | IgG2b |
| Specificity | H 13 recognizes a C3a-determinant (eg C3 alpha-chain) which is present also on native C3. H 13 allows discrimination of ubiquitous or nonspecifically bound native C3 from biologically active C3b fragment; C3b or C are negative with H 13. |
| Reactivity | Guinea Pig, Human, Rabbit |
| Applications | IHC, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Burger, R.et al. (1987) Clin Exp. Immunol. 68: 703-711Sugita, K. et al. (1987) Transplantation 43: 4 570-574Burger R et al. (1989) Aerztl Lab 35: 265-270Zillow G et al. (1989) J Immunol Methods 121: 261-268 |
| Background | Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. |
| Supplier | ARP |
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