Anti-CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker), Monoclonal Antibody
| Product Name | Anti-CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells._Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors. |
| Synonyms | Carbamoyl-phosphate synthetase 1 (CPS1), Carbamoylphosphate synthetase 1, CPSase 1, CPSASE1 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPM615 |
| Immunogen | Recombinant human CPS1 protein |
| Isotype | IgG1 |
| Reactivity | Canine, Human |
| Applications | IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 1373 |
| Uniprot | P31327 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Haraguchi, Y., et al. 1991. Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperam- monemia. Gene 107: 335-340. Ramos-Vara, J.A., et al. Histochem 2002; J. 34: 397-401.Fan, Z., et al. Mod. Pathol 2003; 16: 137-144, 2003. |
| Supplier | ARP |
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