| Product Name | Anti-CREB5 Antibody [PCRP-CREB5-1G8] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [PCRP-CREB5-1G8] antibody to CREB5. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-CREB5-1G8 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human CREB5 protein. |
| Isotype | IgG2b |
| Molecular Weight | 57 kDa |
| Target | CREB5 |
| Specificity | The ATF/CREB family consists of a series of transcription factors that function by binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2 (also designated ATF-4), CRE-BPa, LZIP (also designated CREB-3 and Luman), CREM-2, ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 and ATF-7. These transcription factors share terminal leucine zipper dimerization and basic DNA binding domains and are highly variable in their N-termini. Although each of the ATF/ CREB proteins bind CREs in their homodimeric form, they can also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. Protein kinase A- mediated CREB phosphorylation induces association with a nuclear protein designated CBP (CREB-binding protein), which may represent a CREB coactivator. CRE-BPa is a nuclear protein that binds DNA as a homodimer but can also form a heterodimer with ATF-2 or Jun. |
| Reactivity | Human |
| Applications | FC, IF, WB |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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